Basic Information


GTO ID GTC1680
Trial ID NCT02988258
Disease Hematologic Cancer
Altered gene CMV
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment CMV TCR-T cells
HLAHLA-A*02:01
PhasePhase1
Recruitment statusSuspended
TitleCMV TCR Gene Therapy: A Phase I Safety, Toxicity and Feasibility Study of Adoptive Immunotherapy With CMV TCR-transduced Donor-derived T Cells for Recipients of Allogeneic Haematopoietic Stem Cell Transplantation
Year2012
CountryUnited Kingdom
Company sponsorUniversity College, London
Other ID(s)UCL 08/0214|2008-006649-18|G0701703|08/0214
Vector information
Vectorretrovirus

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 1E3 cells
Donor type Allogeneic
Age Adult, Older_Adult
Lymph depletion No
Cohort2: dose level 2
Administration route infusion
Dosage 1E4 cells
Donor type Allogeneic
Age Adult, Older_Adult
Lymph depletion No
Cohort3: dose level 3
Administration route infusion
Dosage 1E5 cells
Donor type Allogeneic
Age Adult, Older_Adult
Lymph depletion No

Relationship Graph

Overview of Knowledge Graph