Basic Information

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC1673
Trial ID NCT02965157
Disease B-Cell Lymphoma
Altered gene CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD20 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusUnknown
TitlePilot Study of Anti-CD20-CAR-engineered T Cells in Patients With Chemotherapy Resistant or Refractory CD20+ Lymphoma
Year2016
CountryChina
Company sponsorBeijing Biohealthcare Biotechnology Co., Ltd
Other ID(s)EY201605-19
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ
Transgene/Inserted geneCD20 targeting antibody scFv; two intracellular signaling domains derived from CD3 zeta and CD28

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 15
Age Adult, Older_Adult

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