Basic Information

Gene symbol CD274 Synonyms B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD274 molecule

GTO ID GTC1660
Trial ID NCT02937844
Disease Brain Glioblastoma Multiforme
Altered gene PD-L1
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment PD-L1 CAR-T cells
PhasePhase1
Recruitment statusUnknown
TitlePilot Study of Autologous Chimeric Switch Receptor Modified T Cells in Recurrent Glioblastoma Multiforme
Year2016
CountryChina
Company sponsorBeijing Sanbo Brain Hospital
Other ID(s)SBNK-2016-016-01

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E4 cells/kg, 1E7 cells/kg
Donor type Autologous
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes

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