Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1654
Trial ID NCT02933775
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitleCD19-redirected Autologous Cells (CAR-CD19 T Cells)
Year2016
CountryChina
Company sponsorRenJi Hospital
Other ID(s)CG3001
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ|scFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1~10E7 cells/kg, 1~3 infusions
Donor type Autologous
Pts 45
Age Adult, Older_Adult
Lymph depletion Yes

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