Basic Information

Gene symbol GPC3 Synonyms DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 Type of gene protein-coding
Description glypican 3

GTO ID GTC1653
Trial ID NCT02932956
Disease Liver Cancer
Altered gene GPC3
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GPC3 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleGlypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Patients With Pediatric Solid Tumors (GAP)
Year2018
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-39410- GAP|GAP
Vector information
Vectorretrovirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneanti GC33 CART

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E7 cells/m^2, 3E7 cells/m^2, 1E8 cells/m^2, 3E8 cells/m^2, 1E9 cells/m^2
Donor type Autologous
Pts 10
Age Child, Adult
Lymph depletion Yes
References PMID: 30873384

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