Basic Information

Gene symbol EPCAM Synonyms Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, LYNCH8, M4S1, MIC18, MK-1, MOC-31, TACSTD1, TROP1 Type of gene protein-coding
Description epithelial cell adhesion molecule

GTO ID GTC1646
Trial ID NCT02915445
Disease Nasopharynx Carcinoma | Stomach Cancer | Breast Cancer
Altered gene EpCAM
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment EpCAM CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleEpCAM CAR-T for Treatment of Advanced Solid Tumors
Year2016
CountryChina
Company sponsorSichuan University
Other ID(s)SKLB-083
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ
Transgene/Inserted genesingle-chain variable fragment derived from clone FMC63; extracellular domain; transmembrane regions of CD8α; intracellular domain of 4-1BB (CD137); intracellular domain of CD3ζ
Regulatory elementEF1α promoter; SV40 poly(A) signal sequence

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 30
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36045296

Relationship Graph

Overview of Knowledge Graph