Basic Information

Gene symbol PDCD1 Synonyms CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description programmed cell death 1

GTO ID GTC1633
Trial ID NCT02863913
Disease Invasive Bladder Cancer
Altered gene PDCD1
Therapeutic/Target gene Target gene
TherapyGene editing
Treatment PD-1 Knockout T cells
PhasePhase1
Recruitment statusWithdrawn
TitleA Dose-escalation Phase I Trial of PD-1 Knockout Engineered T Cells for the Treatment of Muscle-invasive Bladder Cancer
Year2016
CountryChina
Company sponsorPeking University
Other ID(s)11007965938

Clinical Result

Cohort 1
Administration route infusion
Dosage 2E7 cells/kg, a total of 2, 3, 4 cycles of treatment. Each cycle is divided into three administrations, with 20%, 30% and 50% respectively.
Donor type autologous
Pts 0
Age Adult, Older_Adult
Lymph depletion Yes

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