Basic Information

Gene symbol F Synonyms None Type of gene protein-coding
Description Fusion protein (F)

GTO ID GTC1625
Trial ID NCT02830932
Disease Respiratory Syncytial Virus Infectious Disease
Altered gene F
Therapeutic/Target gene Therapeutic gene
TherapydsRNA
Treatment VXA-RSV-f
PhasePhase1
Recruitment statusCompleted
TitleA Phase 1, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Trial to Determine the Safety and Immunogenicity of an Adenoviral-Vector Based Respiratory Syncytial Virus (RSV) F Protein Vaccine (VXA-RSV-f) Expressing Protein F and dsRNA Adjuvant Administered Orally to Healthy Volunteers
Year2016
CountryUnited States
Company sponsorVaxart
Other ID(s)VXA-RSV-101
Vector information
Vectoradenovirus
Transgene/Inserted genea full-length F protein gene from Respiratory Syncytial Virus (RSV)
Viral genome modificationThe E1 and partial E3 regions of the parental adenovirus DNA are deleted.

Clinical Result

Cohort1: VXA-RSV-f_dose level 2
Administration route oral
Dosage VXA-RSV-f, high dose, Singe dose
Age Adult
Cohort2: VXA-RSV-f_dose level 1
Administration route oral
Dosage VXA-RSV-f, low dose, Singe dose
Age Adult
Cohort3: Placebo
Administration route oral
Age Adult

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