Basic Information

Gene symbol GCGR Synonyms GGR, GL-R, MVAH Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description glucagon receptor

GTO ID GTC1623
Trial ID NCT02824003
Disease Type 2 Diabetes Mellitus
Altered gene GCGR
Therapeutic/Target gene Target gene
TherapyASO
Treatment ISIS-GCGRRx|Isis 449884
PhasePhase2
Recruitment statusCompleted
TitleDouble Blind, Randomized, Placebo-Controlled, Phase 2A Mechanistic Study to Evaluate the Effect of ISIS 449884 (ISIS-GCGRRx) on Hepatic Lipid and Glycogen Content in Patients With Type 2 Diabetes Being Treated With Metformin
Year2016
CountryAustria
Company sponsorIonis Pharmaceuticals, Inc.
Other ID(s)ISIS 449884-CS3
Vector information
VectorNo vector was used

Clinical Result

Cohort1: Placebo
Administration route subcutaneous injection
Dosage ISIS-GCGRRx, 100 mg, once weekly dosing for 13 weeks
Pts 5
Age Adult, Older_Adult
References PMID: 30765435
Cohort2: ISIS-GCGRRx
Administration route subcutaneous injection
Pts 10
Age Adult, Older_Adult
References PMID: 30765435

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