Gene symbol | PRAME | Synonyms | CT130, MAPE, OIP-4, OIP4 | Type of gene | protein-coding |
Chromosome | 22 | Map location | 22q11.22 | dbXrefs | |
Description | PRAME nuclear receptor transcriptional regulator |
GTO ID | GTC1608 |
Trial ID | NCT02743611 |
Disease | Uveal Melanoma | Acute Myeloid Leukemia | Myelodysplastic Syndrome |
Altered gene | PRAME |
Therapeutic/Target gene | Target gene |
Therapy | TCR-T cell |
Treatment | BPX-701 |
Co-treatment | Rimiducid |
HLA | HLA-A*02:01 |
Phase | Phase1|Phase2 |
Recruitment status | Active, Not Recruiting |
Title | A Phase 1/2 Dose-Finding Study to Evaluate the Safety, Feasibility, and Activity of BPX-701, a Controllable PRAME T-Cell Receptor Therapy, in HLA-A2+ Subjects With AML, Previously Treated MDS, or Metastatic Uveal Melanoma |
Year | 2016 |
Country | United States |
Company sponsor | Bellicum Pharmaceuticals |
Other ID(s) | BP-011 |
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