Basic Information

Gene symbol PRAME Synonyms CT130, MAPE, OIP-4, OIP4 Type of gene protein-coding
Description PRAME nuclear receptor transcriptional regulator

GTO ID GTC1608
Trial ID NCT02743611
Disease Uveal Melanoma | Acute Myeloid Leukemia | Myelodysplastic Syndrome
Altered gene PRAME
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment BPX-701
Co-treatment Rimiducid
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleA Phase 1/2 Dose-Finding Study to Evaluate the Safety, Feasibility, and Activity of BPX-701, a Controllable PRAME T-Cell Receptor Therapy, in HLA-A2+ Subjects With AML, Previously Treated MDS, or Metastatic Uveal Melanoma
Year2016
CountryUnited States
Company sponsorBellicum Pharmaceuticals
Other ID(s)BP-011
Vector information
Vectorretrovirus
Transgene/Inserted geneCD5 antigen recognition domains; CD8α hinge/transmembrane region; 4-1BB co-stimulatory domain; intracellular CD3ζ
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
References PMID: 21771875

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