Detail

Basic Information Clinical Results Relationship Graph

Gene symbol	EWSR1	Synonyms	EWS, EWS-FLI1, bK984G1.4	Type of gene	protein-coding
Chromosome	22	Map location	22q12.2	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas
Description	EWS RNA binding protein 1

GTO ID	GTC1605
Trial ID	NCT02736565
Disease	Ewing Sarcoma
Altered gene	EWSR1
Therapeutic/Target gene	Target gene
Therapy	shRNA
Treatment	Pbi-shRNA EWS/FLI1 Type 1 Lipoplex\|LPX
Phase	Phase1
Recruitment status	Completed
Title	Phase I Trial of Pbi-shRNA EWS/FLI1 Type 1 Lipoplex (LPX) in Subjects With Advanced Ewing's Sarcoma
Year	2016
Country	United States
Company sponsor	Gradalis, Inc.
Other ID(s)	CL-PTL-001

Vector information

Vector	lipoplex

Cohort1: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 1

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.02mg/kg
Age	Child, Adult, Older_Adult

Cohort2: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 2

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.03mg/kg
Age	Child, Adult, Older_Adult

Cohort3: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 3

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.04mg/kg
Age	Child, Adult, Older_Adult

Cohort4: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 4

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.06mg/kg
Age	Child, Adult, Older_Adult

Cohort5: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 5

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.08mg/kg
Age	Child, Adult, Older_Adult

Cohort6: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 6

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.10mg/kg
Age	Child, Adult, Older_Adult

Cohort7: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 7

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.125mg/kg
Age	Child, Adult, Older_Adult

Cohort8: pbi-shRNA EWS/FL/I1 Type 1 Lipoplex_dose level 8

Administration route	intravenous injection
Dosage	pbi-shRNA EWS/FL/I1 Type 1 Lipoplex, 0.156mg/kg
Age	Child, Adult, Older_Adult

Overview of Knowledge Graph