Basic Information

Gene symbol EGFR Synonyms ERBB, ERRP, HER1, mENA, ERBB1, PIG61, NISBD2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description epidermal growth factor receptor

GTO ID GTC1585
Trial ID NCT02664363
Disease Gliosarcoma | Glioblastoma
Altered gene EGFR
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment EGFRvIII CAR-T cells
Generation3rd
PhasePhase1
Recruitment statusTerminated
TitleEGFRvIII CAR T Cells for Newly-Diagnosed WHO Grade IV Malignant Glioma
Year2017
CountryUnited States
Company sponsorDuke University
Other ID(s)Pro00069444
Vector information
Vectorretrovirus
ConstructscFv-CD28-4-1BB-CD3ζ
Transgene/Inserted gene4-1BB; CD3ζ; antibody (mAb) 139 scFv

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 4.5E6 cells/kg, 1.5E7 cells/kg, 4.5E7 cells/kg, 1.5E8 cells/kg
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 29872570

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