Basic Information

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC1580
Trial ID NCT02650414
Disease B-Cell Leukemia | B-Cell Lymphoma
Altered gene CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CAR-T22
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleCD22 Redirected Autologous T Cells for ALL
Year2016
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)15-012219, 823312|UPCC 15CT055
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneAnti-human CD22 scFv; 4-1BB

Clinical Result

Cohort 1
Administration route None
Dosage <50kg: 0.2~1E7 cells/kg, ≥50kg: 1~5E8 cells
Donor type Autologous
Pts 15
Age Child, Adult

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