Basic Information

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC1579
Trial ID NCT02649829
Disease Malignant Pleural Mesothelioma
Altered gene WT1
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment WT1-RNA DC Vaccine
Co-treatment pemetrexed|cisplatin
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleFirst-line Immunotherapy Using Wilms' Tumor Protein 1 (WT1)-Targeted Dendritic Cell Vaccinations for Malignant Pleural Mesothelioma
Year2017
CountryBelgium
Company sponsorUniversity Hospital, Antwerp
Other ID(s)CCRG13-002
Vector information
Vectordendritic cell

Clinical Result

Cohort 1
Administration route intradermal injection
Dosage autologous WT1 mRNA-loaded DCs, 8~10E6 cells
Pts 28
Age Adult, Older_Adult

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