Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1576
Trial ID NCT02640209
Disease Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhaseEarly_Phase1
Recruitment statusTerminated
TitlePilot Trial Of Autologous T Cells Engineered To Express Anti-CD19 Chimeric Antigen Receptor (CART19)In Combination With Ibrutinib In Patients With Relapsed Or Refractory CD19+ Chronic Lymphocytic Leukemia (CLL)Or Small Lymphocytic Lymphoma (SLL)
Year2015
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 18415, 823584

Clinical Result

Cohort 1
Administration route None
Dosage 1~5E8 cells, 10% on Day 1, 30% on Day 1, 60% on Day 2
Donor type Autologous
Pts 20
Age Adult, Older_Adult

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