Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1573
Trial ID NCT02631044
Disease Follicular Lymphoma | Non-Hodgkin's Lymphoma | Mantle Cell Lymphoma | Diffuse Large B-Cell Lymphoma | Primary Mediastinal B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Breyanzi|Lisocabtagene maraleucel|liso-cel|JCAR017
Location approved US, Japan, EU, Switzerland, UK, Canada
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleStudy Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (TRANSCEND-NHL-001)
Year2015
CountryUnited States
Company sponsorJuno Therapeutics, a Subsidiary of Celgene
Other ID(s)17001
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneanti‐CD19 single‐chain variable fragment; 4‐1BB costimulatory motif; CD3ζ T‐cell activation domain

Clinical Result

Cohort 1
Administration route intravenous infusion
Pts 385
Age Adult, Older_Adult
Lymph depletion Yes

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