Basic Information

Gene symbol IL3RA Synonyms CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra Type of gene protein-coding
Description interleukin 3 receptor subunit alpha

GTO ID GTC1569
Trial ID NCT02623582
Disease Acute Myeloid Leukemia
Altered gene CD123
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD123 CAR-T cells
Generation2nd
PhaseEarly_Phase1
Recruitment statusTerminated
TitleCD123 Redirected Autologous T Cells for AML
Year2015
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)823175 - UPCC 04415

Clinical Result

Cohort1: no lymphodepleting
Administration route intravenous infusion
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion No
References DOI: 10.1182/blood.V130.Suppl_1.1359.1359
Cohort2: lymphodepleting
Administration route intravenous infusion
Donor type Autologous
Pts 6
Age Adult, Older_Adult
Lymph depletion Yes
References DOI: 10.1182/blood.V130.Suppl_1.1359.1359

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