Basic Information

Gene symbol ERBB2 Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description erb-b2 receptor tyrosine kinase 2

GTO ID GTC1550
Trial ID NCT02547961
Disease Breast Cancer
Altered gene HER2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment HER2 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusWithdrawn
TitleChimeric Antigen Receptor-Modified T Cells for Breast Cancer
Year2015
CountryChina
Company sponsorFuda Cancer Hospital, Guangzhou
Other ID(s)Breast Cancer CAR-T 001
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ
Transgene/Inserted geneHER-2 targeting antibody scFv with two intracellular signaling domains derived from CD3 zeta and CD28

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 0
Age Adult, Older_Adult

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