Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

GTO ID GTC1542
Trial ID NCT02500849
Disease HIV Infection | AIDS
Altered gene CCR5
Therapeutic/Target gene Target gene
TherapyGene editing
Treatment SB-728mR-HSPC
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleA Pilot Study to Evaluate the Feasibility, Safety and Engraftment of Zinc Finger Nuclease (ZFN) CCR5 Modified CD34+ Hematopoietic Stem/Progenitor Cells (SB-728mR-HSPC) in HIV-1 (R5) Infected Patients
Year2015
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)14017

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 12
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 27900346

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