Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule


GTO ID GTC1538
Trial ID NCT02465983
Disease Pancreatic Cancer
Altered gene MESO|CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/MESO CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusTerminated
TitlePilot Study of Autologous T-cells in Patients With Metastatic Pancreatic Cancer
Year2015
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 19214, 821275|UPCC 19214|UCSF CC144520
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort1: MESO
Administration route intravenous infusion
Dosage 1~3E7 cells/m^2, 1~3E8 cells/m^2
Donor type Autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: CD19
Administration route intravenous infusion
Dosage 1~3E7 cells/m^2, 1~3E8 cells/m^2
Donor type Autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes

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