Basic Information

Gene symbol ERBB2 Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description erb-b2 receptor tyrosine kinase 2

GTO ID GTC1530
Trial ID NCT02442297
Disease Brain Cancer
Altered gene HER2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment HER2 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleT Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors
Year2015
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-31973-iCAR

Clinical Result

Cohort1: Dosing Schedule 1
Administration route None
Dosage Cycle 1A: 1E7 cells, Cycle 2A: 1E7 cells, Cycle 3A: 1E7 cells
Age Child, Adult, Older_Adult
Cohort2: Dosing Schedule 2
Administration route None
Dosage Cycle 1A: 1E7 cells, Cycle 2B: 3E7 cells, Cycle 3B: 3E7 cells
Age Child, Adult, Older_Adult
Cohort3: Dosing Schedule 3
Administration route None
Dosage Cycle 1A: 1E7 cells, Cycle 2B: 3E7 cells, Cycle 3C: 1E8 cells
Age Child, Adult, Older_Adult

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