Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1528
Trial ID NCT02435186
Disease Fallopian Tube Cancer | Ovary Epithelial Cancer | Retroperitoneal Cancer
Altered gene P53
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment rAd-p53
Co-treatment Cisplatin|Paclitaxel
PhasePhase2
Recruitment statusUnknown
TitleRecombinant Adenoviral p53 Human Gene Combined With Chemotherapy in Treatment of Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer
Year2015
CountryChina
Company sponsorShenzhen SiBiono GeneTech Co.,Ltd
Other ID(s)rAd-p53-H20150111
Vector information
Vectoradenovirus
ConstructrAd-p53
Vector typerecombinant adenoviral (rAd) vector
Transgene/Inserted genehuman p53 gene

Clinical Result

Cohort 1
Administration route intraperitoneal injection
Dosage 2E12 vp
Age Adult, Older_Adult
References PMID: 36138802

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