Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1526
Trial ID NCT02429726
Disease Malignant Pleural Effusion
Altered gene P53
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment rAd-p53
PhasePhase2
Recruitment statusUnknown
TitleRecombinant Adenoviral Human p53 Gene With or Without Cisplatin in Treatment of Malignant Pleural - a Phase 2, Double Blinded, Randomized, Active Controlled Study
Year2015
CountryChina
Company sponsorShenzhen SiBiono GeneTech Co.,Ltd
Other ID(s)rAd-p53-H2015002
Vector information
Vectoradenovirus
ConstructrAd-p53
Vector typerecombinant adenoviral (rAd) vector
Transgene/Inserted genehuman p53 gene

Clinical Result

Cohort1: rAdp53
Administration route intracavity infusion
Dosage 2E12 vp
Age Adult, Older_Adult
References PMID: 36138802
Cohort2: rAdp53_Cisplatin
Administration route intracavity infusion
Dosage 2E12 vp
Age Adult, Older_Adult
References PMID: 36138802

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