Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1525
Trial ID NCT02429037
Disease Head and Neck Cancer
Altered gene P53
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment rAd-p53
Co-treatment radiation therapy|Cisplatin
PhasePhase2
Recruitment statusUnknown
TitleRecombinant Adenoviral Human p53 Gene Combined With Radio- and Chemo-therapy in Treatment of Unresectable, Locally Advanced Head and Neck Cancer - a Open-labeled Randomized Phase 2 Study
Year2015
CountryChina
Company sponsorShenzhen SiBiono GeneTech Co.,Ltd
Other ID(s)rAd-p53-J1002
Vector information
Vectoradenovirus
ConstructrAd-p53
Vector typerecombinant adenoviral (rAd) vector
Transgene/Inserted genehuman p53 gene

Clinical Result

Cohort 1
Administration route multi-point injections
Dosage 2E12 vp on day 1, 8 and 15 in a 21-days cycle
Age Adult, Older_Adult
References PMID: 36138802

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