Detail

Basic Information Clinical Results Relationship Graph

Gene symbol	CD40LG	Synonyms	CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L	Type of gene	protein-coding
Chromosome	X	Map location	Xq26.3	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	CD40 ligand

Gene symbol	TLR4	Synonyms	ARMD10, CD284, TLR-4, TOLL	Type of gene	protein-coding
Chromosome	9	Map location	9q33.1	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	toll like receptor 4

GTO ID	GTC1519
Trial ID	NCT02413645
Disease	HIV Infection
Altered gene	CD40LG\|TLR4\|CD70
Therapeutic/Target gene	Therapeutic gene
Therapy	mRNA vaccine
Treatment	iHIVARNA-01
Phase	Phase1
Recruitment status	Completed
Title	A Phase I, Open Label Dose Escalation Study to Evaluate Safety of iHIVARNA-01 in Chronically HIV-infected Patients Under Stable Combined Antiretroviral Therapy
Year	2015
Country	Spain
Company sponsor	Judit Pich Martínez
Other ID(s)	iHIVARNA\|2014-004591-32

Cohort1: TriMix_dose Level

Administration route	intranodal administration
Dosage	TriMix mRNA, 100mg, 3 immunizations (at weeks 0, 2 and 4)
Pts	3
Age	Adult, Older_Adult
References	PMID: 30289805

Cohort2: TriMix_dose Leve2

Administration route	intranodal administration
Dosage	TriMix mRNA, 300mg, 3 immunizations (at weeks 0, 2 and 4)
Pts	3
Age	Adult, Older_Adult
References	PMID: 30289805

Cohort3: HIVACAT_dose Level_TriMix_dose Leve2

Administration route	intranodal administration
Dosage	HIVACAT mRNA, 600mg and TriMix mRNA, 300mg, 3 immunizations (at weeks 0, 2 and 4)
Pts	3
Age	Adult, Older_Adult
References	PMID: 30289805

Cohort4: HIVACAT_dose Leve2_TriMix_dose Leve2

Administration route	intranodal administration
Dosage	HIVACAT mRNA, 900mg and TriMix mRNA, 300mg, 3 immunizations (at weeks 0, 2 and 4)
Pts	3
Age	Adult, Older_Adult
References	PMID: 30289805

Cohort5: HIVACAT_dose Leve3_TriMix_dose Leve2

Administration route	intranodal administration
Dosage	HIVACAT mRNA, 1200mg and TriMix mRNA, 300mg, 3 immunizations (at weeks 0, 2 and 4)
Pts	6
Age	Adult, Older_Adult
References	PMID: 30289805

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