Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1508
Trial ID NCT02348216
Disease High-Grade B-Cell Lymphoma | Follicular Lymphoma | Diffuse Large B-Cell Lymphoma | Primary Mediastinal B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Generation2nd
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleStudy Evaluating the Safety and Efficacy of KTE-C19 in Adult Participants With Refractory Aggressive Non-Hodgkin Lymphoma
Year2015
CountryUnited States
Company sponsorKite, A Gilead Company
Other ID(s)KTE-C19-101|2015-005007-86
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2E6 cells/kg, single infusion
Donor type Autologous
Pts 307
Age Adult, Older_Adult
Lymph depletion Yes

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