Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

GTO ID GTC1505
Trial ID NCT02337985
Disease T-Cell Non-Hodgkin's Lymphoma
Altered gene CCR5
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment rHIV7-shI-TAR-CCR5RZ LV cells
Co-treatment Prednisone|Rituximab|Etoposide|Doxorubicin Hydrochloride|Vincristine Sulfate|Cyclophosphamide|Filgrastim
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleSafety and Feasibility of Stem Cell Gene Transfer Following R-EPOCH for Non-Hodgkin Lymphoma in AIDS Patients Using Peripheral Blood Stem/Progenitor Cells Treated With a Lentivirus Vector-Encoding Multiple Anti-HIV RNAs
Year2014
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)14004|NCI-2014-02416|14004|U01CA183012
Vector information
Vectorlentivirus
Vector typeself-inactivating lentiviral vector
Transgene/Inserted genean siRNA targeting a common exon shared by HIV tat/rev; a nucleolar localizing TAR decoy; an anti-CCR5-specific hammerhead ribozyme

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 20555022

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