Basic Information

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC1500
Trial ID NCT02315612
Disease Acute Lymphoblastic Leukemia | Non-Hodgkin's Lymphoma | Follicular Lymphoma | Large B-Cell Lymphoma
Altered gene CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD22 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleAnti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies
Year2014
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)150029|15-C-0029
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 3E5 cells/kg, 1E6 cells/kg, 3E6 cells/kg
Pts 208
Age Child, Adult
Lymph depletion Yes

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