Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	L1CAM	Synonyms	CAML1, CD171, HSAS, HSAS1, HYCX, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1	Type of gene	protein-coding
Chromosome	X	Map location	Xq28	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	L1 cell adhesion molecule

GTO ID	GTC1499
Trial ID	NCT02311621
Disease	Neuroblastoma
Altered gene	CD171
Therapeutic/Target gene	Target gene
Therapy	CAR-T cell
Treatment	CE7R CAR-T cells
Generation	2nd\|3rd
Phase	Phase1
Recruitment status	Active, Not Recruiting
Title	Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01
Year	2014
Country	United States
Company sponsor	Seattle Children's Hospital
Other ID(s)	ENCIT-01

Vector information

Vector	lentivirus
Construct	scFv-4-1BB-CD3ζ\|scFv-CD28-4-1BB-CD3ζ
Additional feature	EGFRt

Clinical Result

Cohort1: 2nd Generation CE7R CAR T Cells

Administration route	intravenous infusion
Dosage	1E6 cells/kg, 5E6 cells/kg, 1E7 cells/kg, 5E7 cells/kg, 1E8 cells/kg
Age	Child, Adult
Lymph depletion	Yes

Cohort2: 3rd Generation CE7R CAR T Cells

Administration route	intravenous infusion
Dosage	1E6 cells/kg, 5E6 cells/kg, 1E7 cells/kg, 5E7 cells/kg, 1E8 cells/kg
Age	Child, Adult
Lymph depletion	Yes

Cohort3: Long Spacer 2nd Generation CE7R CAR T Cells

Administration route	intravenous infusion
Dosage	1E6 cells/kg, 5E6 cells/kg, 1E7 cells/kg, 5E7 cells/kg, 1E8 cells/kg
Age	Child, Adult
Lymph depletion	Yes

Relationship Graph

Overview of Knowledge Graph