Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1492
Trial ID NCT02243124
Disease Myelodysplastic Syndrome
Altered gene P53
Therapeutic/Target gene Target gene
TherapyASO
Treatment Aezea|Cenersen|EL625|Ol(1)p53
Co-treatment Dexamethasone
PhasePhase1
Recruitment statusTerminated
TitleA Study of Aezea (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome
Year2014
CountryUnited States
Company sponsorEleos, Inc.
Other ID(s)MDS ELP9001
Vector information
VectorNo vector was used

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 0.1 mg/kg/3 h/4 days
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route intravenous infusion
Dosage 0.2 mg/kg/3 h/4 days)
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route intravenous infusion
Dosage 0.4 mg/kg/3 h/4 days)
Age Adult, Older_Adult

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