Basic Information


GTO ID GTC1483
Trial ID NCT02159716
Disease Epithelial Ovarian Cancer | Malignant Pleural Mesothelioma | Pancreatic Adenocarcinoma
Altered gene MESO
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MESO CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleCART-meso in Mesothelin Expressing Cancers
Year2014
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 31213, 819826
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 1~3E7 cells/m^2
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route None
Dosage 1~3E8 cells/m^2
Age Adult, Older_Adult

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