Basic Information

Gene symbol IL3RA Synonyms CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra Type of gene protein-coding
Description interleukin 3 receptor subunit alpha

GTO ID GTC1482
Trial ID NCT02159495
Disease Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Blastic Plasmacytoid Dendritic Cell Neoplasm | Acute Biphenotypic Leukemia
Altered gene CD123
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD123 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleGenetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm
Year2014
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)13272|NCI-2014-01147|13272
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous|Allogeneic
Pts 31
Age Child, Adult, Older_Adult
Lymph depletion Yes

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