Basic Information

Gene symbol AR Synonyms AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description androgen receptor

GTO ID GTC1481
Trial ID NCT02144051
Disease Advanced Solid Tumor
Altered gene AR
Therapeutic/Target gene Target gene
TherapyASO
Treatment AZD5312|ISIS 560131|ARRx
PhasePhase1
Recruitment statusCompleted
TitleA Phase I, Open-Label, Multicentre Dose-Escalation Study to Investigate the Safety and Pharmacokinetics of AZD5312 in Patients With Advanced Solid Tumours Where the Androgen Receptor Pathway is a Potential Factor
Year2014
CountryUnited Kingdom|United States
Company sponsorAstraZeneca
Other ID(s)D5860C00001
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage AZD5312, 4 times within the first 11 days, (on Days [1, 4, 8 and 11]± 2), weekly treatments on Days 15 and 22 to complete Cycle, During the subsequent cycles, patients will receive weekly treatment on Days 1, 8, 15 and 22 (±2)
Pts 32
Age Adult, Older_Adult

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