Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	CD19	Synonyms	B4, CVID3	Type of gene	protein-coding
Chromosome	16	Map location	16p11.2	dbXrefs
Description	CD19 molecule

GTO ID	GTC1479
Trial ID	NCT02134262
Disease	B-Cell Non-Hodgkin's Lymphoma
Altered gene	CD19
Therapeutic/Target gene	Target gene
Therapy	CAR-T cell
Treatment	CD19 CAR-T cells
Phase	Phase1\|Phase2
Recruitment status	Unknown
Title	Gene Therapy for B-Cell Non-Hodgkin Lymphoma Using CD19 CAR Gene Transduced T Lymphocytes
Year	2014
Country	Japan
Company sponsor	Jichi Medical University
Other ID(s)	JMU-CD19CAR

Clinical Result

Cohort1: dose level 1

Administration route	intravenous infusion
Dosage	1E5 cells/kg, 2E5 cells/kg
Donor type	Autologous
Age	Adult, Older_Adult
Lymph depletion	Yes

Cohort2: dose level 2

Administration route	intravenous infusion
Dosage	1/3E6 cells/kg, 2/3E6 cells/kg
Donor type	Autologous
Age	Adult, Older_Adult
Lymph depletion	Yes

Cohort3: dose level 3

Administration route	intravenous infusion
Dosage	1E6 cells/kg, 2E6 cells/kg
Donor type	Autologous
Age	Adult, Older_Adult
Lymph depletion	Yes

Cohort4: dose level 4

Administration route	intravenous infusion
Dosage	1/3E7 cells/kg, 2/3E7 cells/kg
Donor type	Autologous
Age	Adult, Older_Adult
Lymph depletion	Yes

Relationship Graph

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