Basic Information

Gene symbol MAGEA4 Synonyms CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B Type of gene protein-coding
Description MAGE family member A4

GTO ID GTC1476
Trial ID NCT02096614
Disease Solid Tumor
Altered gene MAGE-A4
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment TBI-1201
HLAHLA-A*24:02
PhasePhase1
Recruitment statusCompleted
TitleMulti-center, Investigator Initiated Phase 1 Study of MAGE-A4 Specific TCR Gene Transferred T Lymphocytes With Solid Tumors
Year2014
CountryJapan
Company sponsorMie University
Other ID(s)1201-01

Clinical Result

Cohort1: dose level 1_cyclophosphamide
Administration route None
Dosage 5E8 cells
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: dose level 2_cyclophosphamide
Administration route None
Dosage 5E9 cells
Age Adult, Older_Adult
Lymph depletion Yes
Cohort3: dose level 2_cyclophosphamide_fludarabine
Administration route None
Dosage 5E9 cells
Age Adult, Older_Adult
Lymph depletion Yes

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