Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1468
Trial ID NCT02050347
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleActivated T Lymphocytes Expressing CARs, Relapsed CD19+ Malignancies Post-Allo HSCT(CARPASCIO)
Year2014
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-33133 CARPASCIO|CARPASCIO
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort1: dose level 1_residual or relapsed B-cell ALL_HLA-match
Administration route intravenous infusion
Dosage 5E5 cells/kg, 1E6 cells/kg, 5E6 cells/kg
Donor type Autologous
Age Child, Adult, Older_Adult
Lymph depletion Yes
Cohort2: dose level 1_other B-cell malignancies_HLA-matched
Administration route intravenous infusion
Dosage 5E5 cells/kg, 1E6 cells/kg, 5E6 cells/kg
Donor type Autologous
Age Child, Adult, Older_Adult
Lymph depletion Yes
Cohort3: dose level 2_residual or relapsed B-cell ALL_HLA-mismatch
Administration route intravenous infusion
Dosage 1E5 cells/kg, 5E5 cells/kg, 1E6 cells/kg
Donor type Autologous
Age Child, Adult, Older_Adult
Lymph depletion Yes
Cohort4: dose level 2_other B cell malignancies_HLA-mismatch
Administration route intravenous infusion
Dosage 1E5 cells/kg, 5E5 cells/kg, 1E6 cells/kg
Donor type Autologous
Age Child, Adult, Older_Adult
Lymph depletion Yes

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