Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1466
Trial ID NCT02028455
Disease Acute Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleA Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia
Year2014
CountryUnited States
Company sponsorSeattle Children's Hospital
Other ID(s)PLAT-02
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Additional featureEGFRt

Clinical Result

Cohort 1
Administration route None
Dosage 5E5 cells/kg, 1E6 cells/kg, 5E6 cells/kg, 1E7 cells/kg, 5E5 cells/kg
Donor type Autologous
Pts 167
Age Child, Adult
Outcome 38 subjects who achieved an initial sustained MRD-neg remission
References PMID: 30860496

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