Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

GTO ID GTC1460
Trial ID NCT01961063
Disease T-Cell Non-Hodgkin's Lymphoma
Altered gene CCR5
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment rHIV7-shI-TAR-CCR5RZ
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleSafety and Feasibility of Gene Transfer After Frontline Chemotherapy for Non-Hodgkin Lymphoma in AIDS Patients Using Peripheral Blood Stem/Progenitor Cells Treated With a Lentivirus Vector-Encoding Multiple Anti-HIV RNAs
Year2013
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)13282|NCI-2013-01728|13282
Vector information
Vectorlentivirus
Regulatory elementa Woodchuck hepatitis virus post-transcriptional regulatory element (WPRE)

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes

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