Basic Information

Gene symbol tk

GTO ID GTC1457
Trial ID NCT01913106
Disease Prostate Cancer
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment Adv-tk
Co-treatment Valacyclovir|Brachytherapy
PhasePhase1|Phase2
Recruitment statusRecruiting
TitlePhase I-II Study HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer With or Without Metastatic Disease
Year2013
CountryUnited States
Company sponsorThe Methodist Hospital Research Institute
Other ID(s)Pro00000601|IRB 0107-0009
Vector information
Vectoradenovirus
ConstructADV/RSV-tk
Vector typeadenoviral vector
Transgene/Inserted geneherpes simplex virus (HSV) thymidine kinase gene
Regulatory elementa Rous sarcoma virus (RSV) promoter

Clinical Result

Cohort 1
Administration route None
Pts 25
Age Child, Adult, Older_Adult

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