Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	GCGR	Synonyms	GGR, GL-R, MVAH	Type of gene	protein-coding
Chromosome	17	Map location	17q25.3	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	glucagon receptor

GTO ID	GTC1452
Trial ID	NCT01885260
Disease	Type 2 Diabetes Mellitus
Altered gene	GCGR
Therapeutic/Target gene	Target gene
Therapy	ASO
Treatment	ISIS-GCGRRx\|Isis 449884
Phase	Phase2
Recruitment status	Completed
Title	A Double Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability and Efficacy of ISIS 449884 Administered Once Weekly to Patients With Type 2 Diabetes Mellitus Being Treated With Metformin
Year	2013
Country	South Africa\|United States
Company sponsor	Ionis Pharmaceuticals, Inc.
Other ID(s)	ISIS 449884-CS2

Vector information

Vector	No vector was used

Clinical Result

Cohort1: Placebo

Administration route	subcutaneous injection
Pts	26
Age	Adult, Older_Adult
References	PMID: 30765435

Cohort2: ISIS-GCGRRx_dose level1

Administration route	subcutaneous injection
Dosage	ISIS-GCGRRx, 100 mg, 3 doses on alternate days during the first week and then once weekly for 12 weeks
Pts	23
Age	Adult, Older_Adult
References	PMID: 30765435

Cohort3: ISIS-GCGRRx_dose level2

Administration route	subcutaneous injection
Dosage	ISIS-GCGRRx, 200 mg, 3 doses on alternate days during the first week and then once weekly for 12 weeks
Pts	26
Age	Adult, Older_Adult
References	PMID: 30765435

Relationship Graph

Overview of Knowledge Graph