Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1449
Trial ID NCT01860937
Disease T-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleT-Lymphocytes Genetically Targeted to the B-Cell Specific Antigen CD19 in Pediatric and Young Adult Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia
Year2013
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)13-052

Clinical Result

Cohort 1
Administration route None
Dosage 1E6 cells/kg
Pts 25
Age Child, Adult
Lymph depletion Yes
Adverse reactions 4/25(severe cytokine release syndrome); 7/25(severe neurotoxicity)
References PMID: 31650176

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