Basic Information


GTO ID GTC1447
Trial ID NCT01822652
Disease Neuroblastoma
Altered gene GD2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GD2 CAR-T cells
Generation3rd
PhasePhase1
Recruitment statusActive, Not Recruiting
Title3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN
Year2013
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-31493 GRAIN|P01CA094237
Vector information
Vectorretrovirus
ConstructscFv-CD28-OX40-CD3ζ
Additional featureiCaspase9

Clinical Result

Cohort1: iC9-GD2 T Cells_fresh
Administration route intravenous infusion
Dosage 1E8 cells, 1.5E8 cells, 2E8 cells
Pts 11
Age Child, Adult, Older_Adult
Lymph depletion Yes
Cohort2: iC9-GD2 T Cells_frozen
Administration route None
Dosage 1E7 cells, 1E8 cells, 2E8 cells
Age Child, Adult, Older_Adult
Cohort3: iC9-GD2 T Cells_Pembrolizumab
Administration route None
Dosage 1.5E8 cells, 2E8 cells
Age Child, Adult, Older_Adult

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