Basic Information

Gene symbol HA Synonyms None Type of gene protein-coding
Description haemagglutinin

GTO ID GTC1433
Trial ID NCT01688297
Disease Influenza
Altered gene HA
Therapeutic/Target gene Therapeutic gene
TherapydsRNA
Treatment VXA-A1.1|Ad-HA-dsRNA
PhasePhase1
Recruitment statusCompleted
TitleRandomized Phase 1 Double-Blinded Placebo Controlled Trial to Determine the Safety and Immunogenicity of an Adenoviral-Vector Based Seasonal Influenza A Vaccine and dsRNA Adjuvant Administered Orally to Healthy Volunteers
Year2012
CountryUnited States
Company sponsorVaxart
Other ID(s)VXA02-001 & VXA02-003
Vector information
Vectoradenovirus
ConstructAd-HA-dsRNA
Vector typeadenoviral vector
Transgene/Inserted genehaemagglutinin (A/CA/04/2009) transgene
Regulatory elementa cytomegalovirus promoter; a molecular dsRNA hairpin driven by a separate promoter

Clinical Result

Cohort1: VXA-A1.1_dose level 1
Administration route oral
Age Adult
References PMID: 26333337
Cohort2: Placebo
Administration route oral
Age Adult
References PMID: 26333337
Cohort3: VXA-A1.1_dose level 2
Administration route oral
Age Adult
References PMID: 26333337
Cohort4: VXA-A1.1_dose level 3
Administration route oral
Age Adult
References PMID: 26333337

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