| Gene symbol | CD70 | Synonyms | CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A | Type of gene | protein-coding |
| Chromosome | 19 | Map location | 19p13.3 | dbXrefs | |
| Description | CD70 molecule | ||||
| Gene symbol | PMEL | Synonyms | D12S53E, HMB-45, HMB45, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100 | Type of gene | protein-coding |
| Chromosome | 12 | Map location | 12q13.2 | dbXrefs | |
| Description | premelanosome protein | ||||
| Gene symbol | TLR4 | Synonyms | ARMD10, CD284, TLR-4, TOLL | Type of gene | protein-coding |
| Chromosome | 9 | Map location | 9q33.1 | dbXrefs | |
| Gene perturbation-related omics dataset | PerturbAtlas | PertOrg | ||||
| Description | toll like receptor 4 | ||||
| Gene symbol | TYR | Synonyms | ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | Type of gene | protein-coding |
| Chromosome | 11 | Map location | 11q14.3 | dbXrefs | |
| Gene perturbation-related omics dataset | PerturbAtlas | ||||
| Description | tyrosinase | ||||
| GTO ID | GTC1412 |
| Trial ID | NCT01530698 |
| Disease | Melanoma |
| Altered gene | gp100|TYR|TLR4|CD70 |
| Therapeutic/Target gene | Therapeutic gene |
| Therapy | mRNA vaccine |
| Treatment | total tumor mRNA loaded DOTAP liposome Vaccine |
| Co-treatment | cytokines|TLR ligand |
| Phase | Phase1|Phase2 |
| Recruitment status | Completed |
| Title | Single-step Antigen Loading and TLR Activation of Dendritic Cells by mRNA Electroporation for Vaccination in Stage III and IV Melanoma Patients |
| Year | 2010 |
| Country | Netherlands |
| Company sponsor | Radboud University Medical Center |
| Other ID(s) | NL2009-015737-73|2009-015737-73|AMO2009-084 |
| Vector information | |||
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| Cohort1: single step DC treatment | |||||
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| Cohort2: two step DC treatment | |||||
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