Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC1402
Trial ID NCT01486771
Disease Proliferative Diabetic Retinopathy
Altered gene VEGFA
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment Macugen|pegaptanib|EYE001
PhasePhase4
Recruitment statusUnknown
TitleA Pilot Study to Determine if Intravitreal Injections of Pegaptanib Sodium (Macugen) Given Every 12 Weeks for a Year After an Induction Phase of Three Injections Every 6 Weeks Will Reduce the Progression of Proliferative Diabetic Retinopathy in Patients Without Significant Vitreous Hemorrhage in Comparison to Treatment With Retinal Photocoagulation Alone and After an Induction Phase
Year2007
CountryUnited States
Company sponsorValley Retina Institute
Other ID(s)MPDRS-ED

Clinical Result

Cohort1: Macugen
Administration route intravitreal injection
Dosage Macugen, Q6Arm, then 3 additional injections at 12-week intervals
Age Adult, Older_Adult
Cohort2: Pan Retinal Photocoagulation
Administration route intravitreal injection
Age Adult, Older_Adult

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