Basic Information

Gene symbol HSPB1 Synonyms CMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, HSP27, HSP28, Hsp25, SRP27 Type of gene protein-coding
Description heat shock protein family B (small) member 1

GTO ID GTC1396
Trial ID NCT01454089
Disease Bladder Cancer
Altered gene Hsp27
Therapeutic/Target gene Target gene
TherapyASO
Treatment OGX-427|Apatorsen
Co-treatment Gemcitabine|Cisplatin|Carboplatin
PhasePhase2
Recruitment statusCompleted
TitleA Randomized, Double-blind Phase 2 Study Comparing Gemcitabine and Cisplatin in Combination With OGX-427 or Placebo in Patients With Advanced Transitional Cell Carcinoma
Year2011
CountryCanada|France|Germany|Italy|Poland|Spain|United States
Company sponsorAchieve Life Sciences
Other ID(s)OGX-427-02
Vector information
VectorNo vector was used

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 600 mg, three loading doses within a 9-day period, then 600 mg on Days 1, 8 and 15 ofEach 21-day cycle
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route intravenous infusion
Dosage 600 mg, three loading doses within a 9-day period, then 1000 mg on Days 1, 8 and 15 ofEach 21-day cycle
Age Adult, Older_Adult

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