Basic Information


GTO ID GTC1384
Trial ID NCT01355965
Disease Malignant Pleural Mesothelioma
Altered gene MESO
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MESO CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleAutologous Redirected RNA Meso-CIR T Cells
Year2011
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 17510
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneextracellular single chain antibody (scFv) with specificity for mesothelin; a transmembrane domain; an intracellular signaling molecule comprised of the 4-1BB and TCRζ signaling modules; mRNA encoding the mesothelin CAR

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 1E8~1E9 cells, three infusions
Donor type Autologous
Pts 18
Age Adult, Older_Adult
References PMID: 24777247

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