Basic Information

Gene symbol BIRC5 Synonyms API4, EPR-1 Type of gene protein-coding
Description baculoviral IAP repeat containing 5

Gene symbol BRCA1 Synonyms BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description BRCA1 DNA repair associated

Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC1380
Trial ID NCT01334047
Disease Epithelial Ovarian Cancer
Altered gene BRCA1|TERT|BIRC5
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment DC-006 Vaccine
PhasePhase1|Phase2
Recruitment statusTerminated
TitlePhase I/II Trial of Vaccine Therapy in Recurrent Platinum Sensitive Epithelial Ovarian Cancer Patients Using Autologous Dendritic Cells Loaded With Amplified Ovarian Cancer Stem Cell mRNA, hTERT and Survivin.
Year2011
CountryNorway
Company sponsorSteinar Aamdal
Other ID(s)DC-006
Vector information
Vectordendritic cell

Clinical Result

Cohort 1
Administration route intradermal injection
Dosage DC-006, very 4 weeks during the first year, every months during the 2nd and 3rd year only patients show immunological response
Pts 5
Age Adult, Older_Adult

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