Basic Information

Gene symbol APOB Synonyms FCHL2, FLDB, LDLCQ4, apoB-100, apoB-48 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description apolipoprotein B

GTO ID GTC1376
Trial ID NCT01299298
Disease Familial Hypercholesterolemia
Altered gene APOB
Therapeutic/Target gene Target gene
TherapyASO
Treatment ISIS 301012|mipomersen sodium|Kynamro
Location approved US, Mexico, Argentina, South Korea
PhasePhase1
Recruitment statusCompleted
TitleA Prospective, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation, Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Doses of Mipomersen Administered Subcutaneously to Japanese Healthy Subjects
Year2011
CountryGermany
Company sponsorKastle Therapeutics, LLC
Other ID(s)MIPO3700710|2010-021948-18
Vector information
VectorNo vector was used

Clinical Result

Cohort1: mipomersen_dose level 1
Administration route subcutaneous injection
Dosage mipomersen, 50 mg
Age Adult
Cohort2: mipomersen_dose level 2
Administration route subcutaneous injection
Dosage mipomersen, 100mg
Age Adult
Cohort3: mipomersen_dose level 3
Administration route subcutaneous injection
Dosage mipomersen, 200mg
Age Adult
Cohort4: Placebo
Administration route subcutaneous injection
Dosage placebo
Age Adult

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