Basic Information

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC1375
Trial ID NCT01291420
Disease Breast Cancer | Malignant Mesothelioma | Colorectal Cancer | Sarcoma | Glioblastoma | Renal Cell Carcinoma
Altered gene WT1
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment RNA-modified dendritic cells
PhasePhase1|Phase2
Recruitment statusCompleted
TitleTherapeutic Efficacy of Wilms' Tumor Gene (WT1) mRNA-electroporated Autologous Dendritic Cell Vaccination in Patients With Solid Tumors: a Phase I/Feasibility Study
Year2010
CountryBelgium
Company sponsorUniversity Hospital, Antwerp
Other ID(s)CCRG 11-001
Vector information
Vectordendritic cell

Clinical Result

Cohort 1
Administration route intradermal injection
Dosage autologous dendritic cell vaccination, 10*10E6 DC (500 µL)at 5 sites (100 µL/site), 4 biweekly
Pts 48
Age Adult, Older_Adult

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